UniProt functional annotation for P03126



	UniProt functional annotation for P03126

UniProt code: P03126.

Organism: Human papillomavirus type 16.

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus.

Function: Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway. {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000269|PubMed:10523825, ECO:0000269|PubMed:10523853, ECO:0000269|PubMed:8598912, ECO:0000269|PubMed:9326658, ECO:0000269|PubMed:9649509}.

Subunit: Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP and thus forms a complex with human TP53. Interacts with human NFX1 and MAGI3. Interacts with human IRF3; this interaction inhibits the establishment of antiviral state. Interacts with human TYK2; this interaction inhibits JAK-STAT activation by interferon alpha. Interacts with host DLG1; this interaction leads to the proteasomal degradation of DLG1. {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000269|PubMed:10523853, ECO:0000269|PubMed:12140759, ECO:0000269|PubMed:12200142, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:15378012, ECO:0000269|PubMed:15507623, ECO:0000269|PubMed:16507364, ECO:0000269|PubMed:22483108, ECO:0000269|PubMed:23393263, ECO:0000269|PubMed:26789255, ECO:0000269|PubMed:9326658, ECO:0000269|PubMed:9649509}.

Subcellular location: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000269|PubMed:16507364, ECO:0000269|PubMed:22483108}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000269|PubMed:16507364, ECO:0000269|PubMed:22483108}.

Miscellaneous: Belongs to the high risk human alphapapillomavirus family. The cancer-causing human papillomavirus E6 protein has a unique carboxy terminal PDZ domain containing substrate. {ECO:0000255|HAMAP- Rule:MF_04006}.

Similarity: Belongs to the papillomaviridae E6 protein family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Human papillomavirus type 16.
Taxonomy:		Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus.



Function:		Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway. {ECO:0000255\|HAMAP-Rule:MF_04006, ECO:0000269\|PubMed:10523825, ECO:0000269\|PubMed:10523853, ECO:0000269\|PubMed:8598912, ECO:0000269\|PubMed:9326658, ECO:0000269\|PubMed:9649509}.


Subunit:		Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP and thus forms a complex with human TP53. Interacts with human NFX1 and MAGI3. Interacts with human IRF3; this interaction inhibits the establishment of antiviral state. Interacts with human TYK2; this interaction inhibits JAK-STAT activation by interferon alpha. Interacts with host DLG1; this interaction leads to the proteasomal degradation of DLG1. {ECO:0000255\|HAMAP-Rule:MF_04006, ECO:0000269\|PubMed:10523853, ECO:0000269\|PubMed:12140759, ECO:0000269\|PubMed:12200142, ECO:0000269\|PubMed:15371341, ECO:0000269\|PubMed:15378012, ECO:0000269\|PubMed:15507623, ECO:0000269\|PubMed:16507364, ECO:0000269\|PubMed:22483108, ECO:0000269\|PubMed:23393263, ECO:0000269\|PubMed:26789255, ECO:0000269\|PubMed:9326658, ECO:0000269\|PubMed:9649509}.
Subcellular location:		Host cytoplasm {ECO:0000255\|HAMAP-Rule:MF_04006, ECO:0000269\|PubMed:16507364, ECO:0000269\|PubMed:22483108}. Host nucleus {ECO:0000255\|HAMAP-Rule:MF_04006, ECO:0000269\|PubMed:16507364, ECO:0000269\|PubMed:22483108}.
Miscellaneous:		Belongs to the high risk human alphapapillomavirus family. The cancer-causing human papillomavirus E6 protein has a unique carboxy terminal PDZ domain containing substrate. {ECO:0000255\|HAMAP- Rule:MF_04006}.
Similarity:		Belongs to the papillomaviridae E6 protein family. {ECO:0000305}.