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UniProt functional annotation for Q2G2P5 | ||
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| UniProt code: Q2G2P5. |
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| Organism: | |
Staphylococcus aureus (strain NCTC 8325 / PS 47). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import. Binds nickel and transfers it to the membrane-bound permease. Required for full urease activity and plays a significant role in the virulence of S.aureus during urinary tract infection (UTI) (PubMed:20662775). May bind nickel via a nickel-chelator (PubMed:25611161). {ECO:0000269|PubMed:20662775, ECO:0000269|PubMed:25611161}. |
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| Subunit: | |
The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA). {ECO:0000269|PubMed:20662775}. |
| Subcellular location: | |
Cell membrane {ECO:0000255|PROSITE- ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. |
| Induction: | |
Induced in response to decrease in pH and as a function of growth phase. {ECO:0000269|PubMed:20662775}. |
| Disruption phenotype: | |
Deletion of the gene strongly reduces nickel transport and urease activity. Mutant shows decreased virulence in a mouse model of ascending UTI. Nickel accumulation and urease activity are almost completely abolished in a nixA-nikA double mutant. {ECO:0000269|PubMed:20662775}. |
| Similarity: | |
Belongs to the bacterial solute-binding protein 5 family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=ABD29379.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.