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UniProt functional annotation for Q9KFV3 | ||
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| UniProt code: Q9KFV3. |
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| Organism: | |
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus. |
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| Function: | |
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. {ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000269|PubMed:25746996}. |
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| Catalytic activity: | |
Reaction=dCTP + 2 H2O = diphosphate + dUMP + NH4(+); Xref=Rhea:RHEA:19205, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:33019, ChEBI:CHEBI:61481, ChEBI:CHEBI:246422; EC=3.5.4.30; Evidence={ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000269|PubMed:25746996}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:25746996}; |
| Activity regulation: | |
Inhibited by dTTP. {ECO:0000269|PubMed:25746996}. |
| Pathway: | |
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000305}. |
| Subunit: | |
Homotrimer. {ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000269|PubMed:25746996}. |
| Induction: | |
Repressed by both deoxycytidine and thymidine. {ECO:0000269|PubMed:25746996}. |
| Similarity: | |
Belongs to the dCTP deaminase family. {ECO:0000255|HAMAP- Rule:MF_00146}. |
Annotations taken from UniProtKB at the EBI.