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UniProt functional annotation for O60200 | ||
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| UniProt code: O60200. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space. The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space (PubMed:26071602, PubMed:26071601, PubMed:26235513). Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane (PubMed:26071602). {ECO:0000269|PubMed:11907266, ECO:0000269|PubMed:20622808, ECO:0000269|PubMed:20657548, ECO:0000269|PubMed:26071601, ECO:0000269|PubMed:26071602, ECO:0000269|PubMed:26235513}. |
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| Subunit: | |
Interacts with UPS1, UPS2 and UPS3. {ECO:0000269|PubMed:20622808, ECO:0000269|PubMed:20657548, ECO:0000269|PubMed:26071601, ECO:0000269|PubMed:26235513}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. Mitochondrion intermembrane space {ECO:0000269|PubMed:17095012, ECO:0000269|PubMed:20622808, ECO:0000269|PubMed:20657548, ECO:0000269|PubMed:22984289}. |
| Miscellaneous: | |
Present with 3870 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the TRIAP1/MDM35 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.