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PDBsum entry 4xhs
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Transport protein
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PDB id
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4xhs
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References listed in PDB file
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Key reference
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Title
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Crystal structure of human nlrp12 pyd domain and implication in homotypic interaction.
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Authors
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T.Jin,
M.Huang,
J.Jiang,
P.Smith,
T.S.Xiao.
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Ref.
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PLoS One, 2018,
13,
e0190547.
[DOI no: ]
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PubMed id
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Note: In the PDB file this reference is
annotated as "TO BE PUBLISHED". The citation details given above have
been manually determined.
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Abstract
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NLRP12 is a NOD-like receptor that plays multiple roles in both inflammation and
tumorigenesis. Despite the importance, little is known about its mechanism of
action at the molecular level. Here, we report the crystal structure of NLRP12
PYD domain at 1.70 Å fused with an maltose-binding protein (MBP) tag.
Interestingly, the PYD domain forms a dimeric configuration through a disulfide
bond in the crystal. The possible biological significance is discussed in the
context of ROS induced NF-κB activation.
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