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UniProt functional annotation for P21816 | ||
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| UniProt code: P21816. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Catalytic activity: | |
Reaction=L-cysteine + O2 = 3-sulfino-L-alanine + H(+); Xref=Rhea:RHEA:20441, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35235, ChEBI:CHEBI:61085; EC=1.13.11.20; |
| Cofactor: | |
Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit.; |
| Pathway: | |
Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:16611640}. |
| Tissue specificity: | |
Highest levels in liver. Significant expression also in kidney, lung and brain. {ECO:0000269|PubMed:8973325}. |
| Developmental stage: | |
From neonate to weaning. |
| Induction: | |
By increase of sulfur amino acid intake. |
| Ptm: | |
The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen. {ECO:0000269|PubMed:16611640}. |
| Similarity: | |
Belongs to the cysteine dioxygenase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.