PDBsum entry 4xfb

Oxidoreductase

PDB id

4xfb

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Contents

			Protein chain

					186 a.a.

			Metals

					_CL


					_FE

			Waters ×333

PDB id:

4xfb

Links

Name:

Oxidoreductase

Title:

Cysteine dioxygenase variant - c93a at ph 8.0 unliganded

Structure:

Cysteine dioxygenase type 1. Chain: a. Synonym: cysteine dioxygenase type i,cdo-i. Engineered: yes. Mutation: yes

Source:

Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: cdo1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.35Å

R-factor:

0.164

R-free:

0.191

Authors:

C.M.Driggers,P.A.Karplus

Key ref:

C.M.Driggers et al. (2016). Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J Mol Biol, 428, 3999-4012. PubMed id: 27477048 DOI: 10.1016/j.jmb.2016.07.012

Date:

26-Dec-14

Release date:

24-Feb-16

PROCHECK

	Headers

	References

Protein chain

P21816 (CDO1_RAT) - Cysteine dioxygenase type 1 from Rattus norvegicus

Seq: Struc:					200 a.a. 186 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 1 residue position (black cross)



		Enzyme reactions

Enzyme class:

E.C.1.13.11.20 - cysteine dioxygenase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

L-cysteine + O2 = 3-sulfino-L-alanine + H⁺

L-cysteine	+	O2	=	3-sulfino-L-alanine	+	H(+)

Cofactor:

Fe(2+); NADH or NADPH

Fe(2+)	NADH	or	NADPH

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1016/j.jmb.2016.07.012	J Mol Biol 428:3999-4012 (2016)
PubMed id: 27477048

Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase.
C.M.Driggers, K.M.Kean, L.L.Hirschberger, R.B.Cooley, M.H.Stipanuk, P.A.Karplus.

ABSTRACT

No abstract given.