|
|
||
|
|
|
|
|
UniProt functional annotation for A0A0H2UL04 | ||
|
|
|
|
|
|
||
| UniProt code: A0A0H2UL04. |
|
||
| Organism: | |
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio. |
|
||
|
||
| Function: | |
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. {ECO:0000256|HAMAP-Rule:MF_01987}. |
|
||
| Catalytic activity: | |
Reaction=ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+); Xref=Rhea:RHEA:13697, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:47013, ChEBI:CHEBI:78346, ChEBI:CHEBI:456216; EC=2.7.1.15; Evidence={ECO:0000256|ARBA:ARBA00000691, ECO:0000256|HAMAP-Rule:MF_01987}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-Rule:MF_01987}; Note=Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. {ECO:0000256|HAMAP-Rule:MF_01987}; |
| Activity regulation: | |
Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity. {ECO:0000256|HAMAP-Rule:MF_01987}. |
| Pathway: | |
Carbohydrate metabolism; D-ribose degradation; D-ribose 5- phosphate from beta-D-ribopyranose: step 2/2. {ECO:0000256|HAMAP- Rule:MF_01987}. |
| Subunit: | |
Homodimer. {ECO:0000256|HAMAP-Rule:MF_01987}. |
| Subcellular location: | |
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01987}. |
| Similarity: | |
Belongs to the carbohydrate kinase PfkB family. {ECO:0000256|ARBA:ARBA00010688, ECO:0000256|RuleBase:RU003704}. |
| Similarity: | |
Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily. {ECO:0000256|HAMAP-Rule:MF_01987}. |
| Similarity: | |
Belongs to the carbohydrate kinase pfkB family. {ECO:0000256|ARBA:ARBA00005380}. |
Annotations taken from UniProtKB at the EBI.