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UniProt functional annotation for Q96EL1 | ||
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| UniProt code: Q96EL1. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847). {ECO:0000269|PubMed:26607847}. |
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| Subunit: | |
Interacts with PAK4 (PubMed:26607847). {ECO:0000269|PubMed:26607847}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:26607847}. Cytoplasm {ECO:0000269|PubMed:26607847}. Note=Mainly nuclear (PubMed:26607847). Relocalizes to the cytoplasm following interaction with PAK4 (PubMed:26607847). {ECO:0000269|PubMed:26607847}. |
| Domain: | |
Contains 2 Inka boxes (also named iBox or inca box) (PubMed:26607847). The Inka boxes bind and inhibit PAK4 by binding a substrate-like manner (PubMed:26607847). {ECO:0000269|PubMed:26607847}. |
| Similarity: | |
Belongs to the INKA family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.