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PDBsum entry 4xbd
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Hydrolase/hydrolase inhibitor
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PDB id
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4xbd
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References listed in PDB file
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Key reference
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Title
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Structure-Guided design and optimization of dipeptidyl inhibitors of norovirus 3cl protease. Structure-Activity relationships and biochemical, X-Ray crystallographic, Cell-Based, And in vivo studies.
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Authors
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A.C.Galasiti kankanamalage,
Y.Kim,
P.M.Weerawarna,
R.A.Uy,
V.C.Damalanka,
S.R.Mandadapu,
K.R.Alliston,
N.Mehzabeen,
K.P.Battaile,
S.Lovell,
K.O.Chang,
W.C.Groutas.
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Ref.
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J Med Chem, 2015,
58,
3144-3155.
[DOI no: ]
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PubMed id
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Abstract
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Norovirus infection constitutes the primary cause of acute viral
gastroenteritis. There are currently no vaccines or norovirus-specific antiviral
therapeutics available for the management of norovirus infection. Norovirus
3C-like protease is essential for viral replication, consequently, inhibition of
this enzyme is a fruitful avenue of investigation that may lead to the emergence
of antinorovirus therapeutics. We describe herein the optimization of dipeptidyl
inhibitors of norovirus 3C-like protease using iterative SAR, X-ray
crystallographic, and enzyme and cell-based studies. We also demonstrate herein
in vivo efficacy of an inhibitor using the murine model of norovirus infection.
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