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PDBsum entry 4xau
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References listed in PDB file
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Key reference
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Title
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Structural characterization of atms13, A putative sugar aminotransferase involved in indolocarbazole at2433 aminopentose biosynthesis.
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Authors
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S.Singh,
Y.Kim,
F.Wang,
L.Bigelow,
M.Endres,
M.K.Kharel,
G.Babnigg,
C.A.Bingman,
A.Joachimiak,
J.S.Thorson,
G.N.Phillips.
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Ref.
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Proteins, 2015,
83,
1547-1554.
[DOI no: ]
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PubMed id
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Abstract
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AT2433 from Actinomadura melliaura is an indolocarbazole antitumor antibiotic
structurally distinguished by its unique aminodideoxypentose-containing
disaccharide moiety. The corresponding sugar nucleotide-based biosynthetic
pathway for this unusual sugar derives from comparative genomics where AtmS13
has been suggested as the contributing sugar aminotransferase (SAT).
Determination of the AtmS13 X-ray structure at 1.50-Å resolution reveals it as
a member of the aspartate aminotransferase fold type I (AAT-I). Structural
comparisons of AtmS13 with homologous SATs that act upon similar substrates
implicate potential active site residues that contribute to distinctions in
sugar C5 (hexose vs. pentose) and/or sugar C2 (deoxy vs. hydroxyl) substrate
specificity. Proteins 2015; 83:1547-1554. © 2015 Wiley Periodicals, Inc.
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