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UniProt functional annotation for B4V386 | ||
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| UniProt code: B4V386. |
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| Organism: | |
Streptomyces sp. Mg1. |
| Taxonomy: | |
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces. |
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| Function: | |
Involved in both the histidine and tryptophan biosynthetic pathways. {ECO:0000256|HAMAP-Rule:MF_01014}. |
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| Catalytic activity: | |
Reaction=1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D- ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5- phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:15469, ChEBI:CHEBI:58435, ChEBI:CHEBI:58525; EC=5.3.1.16; Evidence={ECO:0000256|ARBA:ARBA00000901, ECO:0000256|HAMAP- Rule:MF_01014}; |
| Catalytic activity: | |
Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2- carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate; Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613; EC=5.3.1.24; Evidence={ECO:0000256|HAMAP-Rule:MF_01014}; |
| Pathway: | |
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. {ECO:0000256|ARBA:ARBA00005133, ECO:0000256|HAMAP-Rule:MF_01014}. |
| Pathway: | |
Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 3/5. {ECO:0000256|HAMAP- Rule:MF_01014}. |
| Subcellular location: | |
Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|HAMAP-Rule:MF_01014}. |
| Similarity: | |
Belongs to the HisA/HisF family. {ECO:0000256|ARBA:ARBA00009667, ECO:0000256|HAMAP-Rule:MF_01014, ECO:0000256|RuleBase:RU003657}. |
Annotations taken from UniProtKB at the EBI.