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PDBsum entry 4x6d
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Immune system
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PDB id
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4x6d
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Contents |
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267 a.a.
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86 a.a.
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218 a.a.
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78 a.a.
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189 a.a.
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241 a.a.
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200 a.a.
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References listed in PDB file
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Key reference
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Title
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αβ T cell antigen receptor recognition of cd1a presenting self lipid ligands.
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Authors
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R.W.Birkinshaw,
D.G.Pellicci,
T.Y.Cheng,
A.N.Keller,
M.Sandoval-Romero,
S.Gras,
A.De jong,
A.P.Uldrich,
D.B.Moody,
D.I.Godfrey,
J.Rossjohn.
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Ref.
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Nat Immunol, 2015,
16,
258-266.
[DOI no: ]
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PubMed id
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Abstract
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A central paradigm in αβ T cell-mediated immunity is the simultaneous
co-recognition of antigens and antigen-presenting molecules by the αβ T cell
antigen receptor (TCR). CD1a presents a broad repertoire of lipid-based
antigens. We found that a prototypical autoreactive TCR bound CD1a when it was
presenting a series of permissive endogenous ligands, while other lipid ligands
were nonpermissive to TCR binding. The structures of two TCR-CD1a-lipid
complexes showed that the TCR docked over the A' roof of CD1a in a manner that
precluded direct contact with permissive ligands. Nonpermissive ligands
indirectly inhibited TCR binding by disrupting the TCR-CD1a contact zone. The
exclusive recognition of CD1a by the TCR represents a previously unknown
mechanism whereby αβ T cells indirectly sense self antigens that are bound to
an antigen-presenting molecule.
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