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PDBsum entry 4x3f
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References listed in PDB file
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Key reference
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Title
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The crystal structure of the catalytic domain of the ser/thr kinase pkna from m. Tuberculosis shows an src-Like autoinhibited conformation.
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Authors
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T.Wagner,
M.Alexandre,
R.Duran,
N.Barilone,
A.Wehenkel,
P.M.Alzari,
M.Bellinzoni.
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Ref.
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Proteins, 2015,
83,
982-988.
[DOI no: ]
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PubMed id
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Abstract
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Signal transduction mediated by Ser/Thr phosphorylation in Mycobacterium
tuberculosis has been intensively studied in the last years, as its genome
harbors eleven genes coding for eukaryotic-like Ser/Thr kinases. Here we
describe the crystal structure and the autophosphorylation sites of the
catalytic domain of PknA, one of two protein kinases essential for pathogen's
survival. The structure of the ligand-free kinase domain shows an auto-inhibited
conformation similar to that observed in human Tyr kinases of the Src-family.
These results reinforce the high conservation of structural hallmarks and
regulation mechanisms between prokaryotic and eukaryotic protein kinases.
Proteins 2015; 83:982-988. © 2015 Wiley Periodicals, Inc.
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