PDBsum entry 4x2r

Isomerase

PDB id: 4x2r

Contents

Protein chain

243 a.a.

Ligands

PO4 ×4

CXS

Waters ×305

PDB id:

4x2r

Name:

Isomerase

Title:

Crystal structure of pria from actinomyces urogenitalis

Structure:

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. Chain: a. Synonym: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. Engineered: yes

Source:

Actinomyces urogenitalis dsm 15434. Organism_taxid: 525246. Gene: hisa, hmpref0058_1848. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.05Å R-factor: 0.123 R-free: 0.141

Authors:

K.Michalska,E.A.Verduzco-Castro,M.Endres,F.Barona-Gomez,A.Joachimiak, Midwest Center For Structural Genomics (Mcsg)

Key ref:

K.Michalska et al. Crystal structure of pria from actinomyces urogenital. To be published, . PubMed id: 28362260

Date:

26-Nov-14 Release date: 24-Dec-14

Protein chain

C0W7K4  (C0W7K4_9ACTO) -  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase from Actinomyces urogenitalis DSM 15434

Seq: 247 a.a.

Struc: 243 a.a.

Enzyme reactions

• Enzyme class: E.C.5.3.1.16 - 1-(5-phosphoribosyl)-5-
• Pathway: Histidine Biosynthesis (early stages)
• Reaction: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D- ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1- deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide