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UniProt functional annotation for Q5X159 | ||
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| UniProt code: Q5X159. |
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| Organism: | |
Legionella pneumophila (strain Paris). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Legionellaceae; Legionella. |
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| Function: | |
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. {ECO:0000250|UniProtKB:Q5ZRQ0}. |
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| Catalytic activity: | |
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; |
| Subcellular location: | |
Secreted {ECO:0000250}. Host cell {ECO:0000250}. Note=Secreted via type IV secretion system (T4SS), and delivered into the host cell. {ECO:0000250}. |
| Domain: | |
U-box 1 is critical to the ubiquitin ligase activity, and U-box 2 mediates interaction with host target. {ECO:0000250}. |
| Domain: | |
The 25 C-terminal region may carry the signal responsible for translocation into the host cell. {ECO:0000250}. |
| Ptm: | |
Ubiquitinated in the presence of host E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme and ubiquitin. {ECO:0000250}. |
Annotations taken from UniProtKB at the EBI.