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PDBsum entry 4wn5
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Transcription
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PDB id
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4wn5
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References listed in PDB file
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Key reference
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Title
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Unsaturated fatty acids as high-Affinity ligands of the c-Terminal per-Arnt-Sim domain from the hypoxia-Inducible factor 3α.
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Authors
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A.M.Fala,
J.F.Oliveira,
D.Adamoski,
J.A.Aricetti,
M.M.Dias,
M.V.B.Dias,
M.L.Sforça,
P.S.Lopes-De-Oliveira,
S.A.Rocco,
C.Caldana,
S.M.G.Dias,
A.L.B.Ambrosio.
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Ref.
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Sci Rep, 2015,
5,
12698.
[DOI no: ]
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PubMed id
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Abstract
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Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that
mediate cell responses to hypoxia. The oxygen-dependent stability and activity
of the HIF-α subunits is traditionally associated to post-translational
modifications such as hydroxylation, acetylation, ubiquitination, and
phosphorylation. Here we report novel evidence showing that unsaturated fatty
acids are naturally occurring, non-covalent structural ligands of HIF-3α, thus
providing the initial framework for exploring its exceptional role as a lipid
sensor under hypoxia.
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