UniProt functional annotation for Q5PPM0



	UniProt functional annotation for Q5PPM0

UniProt code: Q5PPM0.

Organism: Xenopus laevis (African clawed frog).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.

Function: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:26755729). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf) and D- phosphoglycerol-modified glycans (PubMed:26755729). Binds to S.pneumoniae serotypes with glycans that contain beta-linked D- galactofuranose (beta-Galf) and with D-phosphoglycerol-modified glycans (PubMed:26755729). Can bind a variety of monosaccharides (in vitro) (PubMed:15537792). Probably plays a role in the defense system against microorganisms (Probable). {ECO:0000269|PubMed:15537792, ECO:0000269|PubMed:26755729, ECO:0000305}.

Subunit: Homotrimer; disulfide-linked (PubMed:26755729). Homohexamer; disulfide-linked (PubMed:15537792, PubMed:26755729). Forms primarily homotrimers in solution, but can also form homohexamers (PubMed:26755729). {ECO:0000269|PubMed:15537792, ECO:0000269|PubMed:26755729}.

Subcellular location: Secreted {ECO:0000269|PubMed:15537792, ECO:0000305|PubMed:26755729}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:15537792}.

Developmental stage: Detected in embryonic epidermal cells; expression increases during neurula and tailbud stage and decreases again after 1 week dpf (at protein level) (PubMed:15537792). First detected in gastrula-stage embryos; expression increases during later stages of embryogenesis. Detected in epidermis and throughout the embryo. {ECO:0000269|PubMed:12802587, ECO:0000269|PubMed:15537792}.

Ptm: N-glycosylated. {ECO:0000269|PubMed:15537792}.

Sequence caution: Sequence=BAC65329.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Xenopus laevis (African clawed frog).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.



Function:		Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:26755729). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf) and D- phosphoglycerol-modified glycans (PubMed:26755729). Binds to S.pneumoniae serotypes with glycans that contain beta-linked D- galactofuranose (beta-Galf) and with D-phosphoglycerol-modified glycans (PubMed:26755729). Can bind a variety of monosaccharides (in vitro) (PubMed:15537792). Probably plays a role in the defense system against microorganisms (Probable). {ECO:0000269\|PubMed:15537792, ECO:0000269\|PubMed:26755729, ECO:0000305}.


Subunit:		Homotrimer; disulfide-linked (PubMed:26755729). Homohexamer; disulfide-linked (PubMed:15537792, PubMed:26755729). Forms primarily homotrimers in solution, but can also form homohexamers (PubMed:26755729). {ECO:0000269\|PubMed:15537792, ECO:0000269\|PubMed:26755729}.
Subcellular location:		Secreted {ECO:0000269\|PubMed:15537792, ECO:0000305\|PubMed:26755729}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269\|PubMed:15537792}.
Developmental stage:		Detected in embryonic epidermal cells; expression increases during neurula and tailbud stage and decreases again after 1 week dpf (at protein level) (PubMed:15537792). First detected in gastrula-stage embryos; expression increases during later stages of embryogenesis. Detected in epidermis and throughout the embryo. {ECO:0000269\|PubMed:12802587, ECO:0000269\|PubMed:15537792}.
Ptm:		N-glycosylated. {ECO:0000269\|PubMed:15537792}.
Sequence caution:		Sequence=BAC65329.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};