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UniProt functional annotation for P0A334 | ||
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| UniProt codes: P0A334, Q54397. |
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| Organism: | |
Streptomyces lividans. |
| Taxonomy: | |
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces. |
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| Function: | |
Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+). {ECO:0000269|PubMed:7489706}. |
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| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:11689936, ECO:0000269|PubMed:9525859}. |
| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. |
| Domain: | |
The cytoplasmic C-terminus is involved in the gating mechanism. |
| Disruption phenotype: | |
Cells grow slower and to lower myceliar densities. {ECO:0000269|PubMed:7489706}. |
| Miscellaneous: | |
The amino acids 62-79 are situated in the membrane and are important for channel structure and properties. |
| Similarity: | |
Belongs to the potassium channel family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.