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PDBsum entry 4ufc
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References listed in PDB file
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Key reference
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Title
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Glycan complexity dictates microbial resource allocation in the large intestine.
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Authors
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A.Rogowski,
J.A.Briggs,
J.C.Mortimer,
T.Tryfona,
N.Terrapon,
E.C.Lowe,
A.Baslé,
C.Morland,
A.M.Day,
H.Zheng,
T.E.Rogers,
P.Thompson,
A.R.Hawkins,
M.P.Yadav,
B.Henrissat,
E.C.Martens,
P.Dupree,
H.J.Gilbert,
D.N.Bolam.
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Ref.
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Nat Commun, 2015,
6,
7481.
[DOI no: ]
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PubMed id
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Abstract
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The structure of the human gut microbiota is controlled primarily through the
degradation of complex dietary carbohydrates, but the extent to which
carbohydrate breakdown products are shared between members of the microbiota is
unclear. We show here, using xylan as a model, that sharing the breakdown
products of complex carbohydrates by key members of the microbiota, such as
Bacteroides ovatus, is dependent on the complexity of the target glycan.
Characterization of the extensive xylan degrading apparatus expressed by B.
ovatus reveals that the breakdown of the polysaccharide by the human gut
microbiota is significantly more complex than previous models suggested, which
were based on the deconstruction of xylans containing limited monosaccharide
side chains. Our report presents a highly complex and dynamic xylan degrading
apparatus that is fine-tuned to recognize the different forms of the
polysaccharide presented to the human gut microbiota.
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