UniProt functional annotation for P0CB20



	UniProt functional annotation for P0CB20

UniProt code: P0CB20.

Organism: Conus striatus (Striated cone).

Taxonomy: Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.

Function: Potently and selectively blocks the desensitization of ionotropic glutamate AMPA receptor (GRIA1, GRIA2, GRIA3 and GRIA4). Can also open already desensitized GRIA1 receptors. Binds to a different site than does the drug cyclothiazide (PubMed:19481459). The toxin acts like a straightjacket on the ligand-binding domain (LBD) 'gating ring' of the receptor, restraining the domains via both intra- and interdimer cross-links such that agonist-induced closure of the LBD 'clamshells' is transduced into an irislike expansion of the gating ring (PubMed:25103405). Application of the toxin to hippocampal slices causes a large and rapid increase in resting AMPAR-mediated current leading to neuronal death (PubMed:19481459). {ECO:0000269|PubMed:19481459, ECO:0000269|PubMed:25103405}.

Subunit: Homodimer; disulfide-linked. {ECO:0000269|PubMed:25103405}.

Subcellular location: Secreted {ECO:0000269|PubMed:19481459}.

Tissue specificity: Expressed by the venom duct. {ECO:0000305}.

Domain: The cysteine framework is CC-CC-C-C-C-CC-C-C-C-C. {ECO:0000305}.

Mass spectrometry: Mass=9443; Method=MALDI; Evidence={ECO:0000269|PubMed:19481459};

Mass spectrometry: Mass=18868; Method=MALDI; Note=Dimer.; Evidence={ECO:0000269|PubMed:19481459};

Miscellaneous: Ikot-ikot is a Filipino word that translates to 'spinning around' or 'turning around', a reference to the swimming phenotype observed in fish injected with the toxin. {ECO:0000305|PubMed:19481459}.

Annotations taken from UniProtKB at the EBI.


Organism:		Conus striatus (Striated cone).
Taxonomy:		Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.



Function:		Potently and selectively blocks the desensitization of ionotropic glutamate AMPA receptor (GRIA1, GRIA2, GRIA3 and GRIA4). Can also open already desensitized GRIA1 receptors. Binds to a different site than does the drug cyclothiazide (PubMed:19481459). The toxin acts like a straightjacket on the ligand-binding domain (LBD) 'gating ring' of the receptor, restraining the domains via both intra- and interdimer cross-links such that agonist-induced closure of the LBD 'clamshells' is transduced into an irislike expansion of the gating ring (PubMed:25103405). Application of the toxin to hippocampal slices causes a large and rapid increase in resting AMPAR-mediated current leading to neuronal death (PubMed:19481459). {ECO:0000269\|PubMed:19481459, ECO:0000269\|PubMed:25103405}.


Subunit:		Homodimer; disulfide-linked. {ECO:0000269\|PubMed:25103405}.
Subcellular location:		Secreted {ECO:0000269\|PubMed:19481459}.
Tissue specificity:		Expressed by the venom duct. {ECO:0000305}.
Domain:		The cysteine framework is CC-CC-C-C-C-CC-C-C-C-C. {ECO:0000305}.
Mass spectrometry:		Mass=9443; Method=MALDI; Evidence={ECO:0000269\|PubMed:19481459};
Mass spectrometry:		Mass=18868; Method=MALDI; Note=Dimer.; Evidence={ECO:0000269\|PubMed:19481459};
Miscellaneous:		Ikot-ikot is a Filipino word that translates to 'spinning around' or 'turning around', a reference to the swimming phenotype observed in fish injected with the toxin. {ECO:0000305\|PubMed:19481459}.