UniProt functional annotation for Q04067



	UniProt functional annotation for Q04067

UniProt code: Q04067.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Binds to the 18S rRNA but non-specifically (PubMed:10085088). {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:10085088}.

Subunit: The eukaryotic translation initiation factor 3 (eIF-3) core complex is composed of TIF32, PRT1, NIP1, TIF34 and TIF35. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. {ECO:0000269|PubMed:18599441, ECO:0000269|PubMed:9671501}.

Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:14562095}.

Similarity: Belongs to the eIF-3 subunit G family. {ECO:0000255|HAMAP- Rule:MF_03006}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Binds to the 18S rRNA but non-specifically (PubMed:10085088). {ECO:0000255\|HAMAP-Rule:MF_03006, ECO:0000269\|PubMed:10085088}.


Subunit:		The eukaryotic translation initiation factor 3 (eIF-3) core complex is composed of TIF32, PRT1, NIP1, TIF34 and TIF35. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. {ECO:0000269\|PubMed:18599441, ECO:0000269\|PubMed:9671501}.
Subcellular location:		Cytoplasm {ECO:0000255\|HAMAP-Rule:MF_03006, ECO:0000269\|PubMed:14562095}.
Similarity:		Belongs to the eIF-3 subunit G family. {ECO:0000255\|HAMAP- Rule:MF_03006}.