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UniProt functional annotation for P32497 | ||
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| UniProt code: P32497. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:12651896}. |
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| Subunit: | |
The eukaryotic translation initiation factor 3 (eIF-3) core complex is composed of TIF32, PRT1, NIP1, TIF34 and TIF35. A subcomplex of TIF32, NIP1 and PRT1 mediates the interaction with eIF-1, TIF5/eIF-5 and HCR1. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl- tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. TIF32, NIP1 and TIF5/eIF-5 comprise a minimal 40S-ribosome- binding unit. NIP1 interacts with TIF5/eIF-5 and SUI1. {ECO:0000269|PubMed:10075937, ECO:0000269|PubMed:12651896, ECO:0000269|PubMed:16581774, ECO:0000269|PubMed:18599441, ECO:0000269|PubMed:7798228, ECO:0000269|PubMed:9671501, ECO:0000269|PubMed:9722586}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:1332047}. Note=Mainly cytoplasmic. |
| Miscellaneous: | |
Present with 78900 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP- Rule:MF_03002}. |
Annotations taken from UniProtKB at the EBI.