UniProt functional annotation for P28907

UniProt code: P28907.

Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Function:		Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Catalytic activity:		Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000269|PubMed:16690024};
Catalytic activity:		Reaction=NADP(+) + nicotinate = nicotinamide + nicotinate-adenine dinucleotide phosphate; Xref=Rhea:RHEA:38599, ChEBI:CHEBI:17154, ChEBI:CHEBI:32544, ChEBI:CHEBI:58349, ChEBI:CHEBI:75967; EC=2.4.99.20; Evidence={ECO:0000269|PubMed:16690024};
Activity regulation:		ATP inhibits the hydrolyzing activity.
Subcellular location:		Membrane; Single-pass type II membrane protein.
Tissue specificity:		Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. {ECO:0000269|PubMed:9074508}.
Developmental stage:		Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast- forming unit E to colony-forming unit E.
Miscellaneous:		[Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.
Similarity:		Belongs to the ADP-ribosyl cyclase family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.