UniProt functional annotation for Q9HAW0



	UniProt functional annotation for Q9HAW0

UniProt code: Q9HAW0.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}.

Subunit: Component of TFIIIB complexes. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; this complex inhibits the transcription by pol III via its phosphorylation by CK2; YY1 facilitates the TFIIIB-alpha complex formation. Interacts with TBP; this interaction promotes recruitment of BRF2 to TATA box-containing promoters (PubMed:26638071). Interacts with TBP and the BURE sequence (GC-rich sequence downstream from the TATA box) to form a strong ternary complex which is joined by BDP1; this ternary complex stimulates pol III transcription. Forms a trimeric complex composed of TBP, BRF2 and mini-SNAPc complex (SNAP43, SNAP50, and the N-terminal third of SNAP190) on the promoter. Assembly of the TBP-BRF2 complex is stimulated by SNAP190. Interacts with MAF1 and SNAPC4. {ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:12016223, ECO:0000269|PubMed:12391172, ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:14527415, ECO:0000269|PubMed:16227591, ECO:0000269|PubMed:16769183, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:26638071}.

Subcellular location: Nucleus {ECO:0000269|PubMed:17505538}.

Induction: Down-regulated by epigallocatechin gallate (EGCG) treatment. {ECO:0000269|PubMed:17624304}.

Ptm: In response to oxidative stress, Cys-361 is reversibly oxidized to cysteine sulfenic acid. Oxidation of Cys-361 impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress. {ECO:0000269|PubMed:26638071}.

Similarity: Belongs to the TFIIB family. {ECO:0000305}.

Sequence caution: Sequence=AAG35486.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269\|PubMed:11040218, ECO:0000269\|PubMed:11121026, ECO:0000269\|PubMed:11564744, ECO:0000269\|PubMed:26638071}.


Subunit:		Component of TFIIIB complexes. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; this complex inhibits the transcription by pol III via its phosphorylation by CK2; YY1 facilitates the TFIIIB-alpha complex formation. Interacts with TBP; this interaction promotes recruitment of BRF2 to TATA box-containing promoters (PubMed:26638071). Interacts with TBP and the BURE sequence (GC-rich sequence downstream from the TATA box) to form a strong ternary complex which is joined by BDP1; this ternary complex stimulates pol III transcription. Forms a trimeric complex composed of TBP, BRF2 and mini-SNAPc complex (SNAP43, SNAP50, and the N-terminal third of SNAP190) on the promoter. Assembly of the TBP-BRF2 complex is stimulated by SNAP190. Interacts with MAF1 and SNAPC4. {ECO:0000269\|PubMed:11564744, ECO:0000269\|PubMed:12016223, ECO:0000269\|PubMed:12391172, ECO:0000269\|PubMed:12621023, ECO:0000269\|PubMed:14527415, ECO:0000269\|PubMed:16227591, ECO:0000269\|PubMed:16769183, ECO:0000269\|PubMed:17505538, ECO:0000269\|PubMed:26638071}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:17505538}.
Induction:		Down-regulated by epigallocatechin gallate (EGCG) treatment. {ECO:0000269\|PubMed:17624304}.
Ptm:		In response to oxidative stress, Cys-361 is reversibly oxidized to cysteine sulfenic acid. Oxidation of Cys-361 impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress. {ECO:0000269\|PubMed:26638071}.
Similarity:		Belongs to the TFIIB family. {ECO:0000305}.
Sequence caution:		Sequence=AAG35486.1; Type=Erroneous initiation; Evidence={ECO:0000305};