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UniProt functional annotation for P9WNS1 | ||
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| UniProt codes: P9WNS1, P64012. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). {ECO:0000255|HAMAP-Rule:MF_00183}. |
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| Catalytic activity: | |
Reaction=2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D- xylulose 5-phosphate + H(+) + NADPH; Xref=Rhea:RHEA:13717, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57792, ChEBI:CHEBI:58262, ChEBI:CHEBI:58349; EC=1.1.1.267; Evidence={ECO:0000255|HAMAP-Rule:MF_00183}; |
| Cofactor: | |
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000255|HAMAP-Rule:MF_00183}; |
| Pathway: | |
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5- phosphate: step 1/6. {ECO:0000255|HAMAP-Rule:MF_00183}. |
| Similarity: | |
Belongs to the DXR family. {ECO:0000255|HAMAP- Rule:MF_00183}. |
Annotations taken from UniProtKB at the EBI.