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UniProt functional annotation for Q8CFR0 | ||
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| UniProt code: Q8CFR0. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. {ECO:0000269|PubMed:21262840}. |
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| Subunit: | |
Forms homotrimers which can further assemble to form higher- order oligomeric complexes. Interacts with ADGRB3. May interact with ERFE. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion. {ECO:0000269|PubMed:18783346, ECO:0000269|PubMed:21262840, ECO:0000269|PubMed:21378161, ECO:0000269|PubMed:22351773, ECO:0000269|PubMed:23449976}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:18783346}. |
| Tissue specificity: | |
Highest expression in eye, followed by placenta and brain, intermediate expression in adipose tissue and lowest expression in lymph node and testis. {ECO:0000269|PubMed:18783346}. |
| Ptm: | |
Glycosylated, but not with N-linked glycans. {ECO:0000269|PubMed:18783346}. |
Annotations taken from UniProtKB at the EBI.