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UniProt functional annotation for P28289 | ||
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| UniProt code: P28289. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:8002995}. |
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| Subunit: | |
Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin. |
| Subcellular location: | |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25250574}. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269|PubMed:25250574}. |
| Tissue specificity: | |
Highly expressed in the erythrocyte, heart and skeletal muscle. |
| Similarity: | |
Belongs to the tropomodulin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.