PDBsum entry 4pf7

Hydrolase/hydrolase inhibitor

PDB id: 4pf7

Contents

Protein chains

955 a.a.

Ligands

2QW ×2

Metals

_ZN ×2

Waters ×578

References listed in PDB file

Key reference

• Title: Dual exosite-Binding inhibitors of insulin-Degrading enzyme challenge its role as the primary mediator of insulin clearance in vivo.
• Authors: T.B.Durham, J.L.Toth, V.J.Klimkowski, J.X.Cao, A.M.Siesky, J.Alexander-Chacko, G.Y.Wu, J.T.Dixon, J.E.Mcgee, Y.Wang, S.Y.Guo, R.N.Cavitt, J.Schindler, S.J.Thibodeaux, N.A.Calvert, M.J.Coghlan, D.K.Sindelar, M.Christe, V.V.Kiselyov, M.D.Michael, K.W.Sloop.
• Ref.: J Biol Chem, 2015, 290, 20044-20059. [DOI no: 10.1074/jbc.M115.638205]
• PubMed id: 26085101

Abstract

No abstract given.