UniProt functional annotation for P0ADY7

UniProt codes: P0ADY7, P02414.

Organism: Escherichia coli (strain K12).
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.
 
Function: This protein binds directly to 23S ribosomal RNA and is located at the A site of the peptidyltransferase center. It contacts the A and P site tRNAs (PubMed:8524654). It has an essential role in subunit assembly, which is not well understood (PubMed:3298242). {ECO:0000269|PubMed:3298242, ECO:0000269|PubMed:8524654}.
 
Subunit: Part of the 50S ribosomal subunit (PubMed:786730, PubMed:10094780, PubMed:12809609, PubMed:16272117, PubMed:25310980, PubMed:24844575, PubMed:27934701, PubMed:27906160, PubMed:27906161). Cross-links to the A and P site tRNAs (PubMed:8524654). {ECO:0000269|PubMed:10094780, ECO:0000269|PubMed:12809609, ECO:0000269|PubMed:16272117, ECO:0000269|PubMed:24844575, ECO:0000269|PubMed:25310980, ECO:0000269|PubMed:27906160, ECO:0000269|PubMed:27906161, ECO:0000269|PubMed:27934701, ECO:0000269|PubMed:786730, ECO:0000269|PubMed:8524654}.
Ptm: Is hydroxylated on Arg-81 by RoxA. The modification is nearly suppressed when E.coli is grown in anoxia. {ECO:0000269|PubMed:23103944}.
Mass spectrometry: Mass=15326.2; Method=MALDI; Evidence={ECO:0000269|PubMed:10094780};
Similarity: Belongs to the universal ribosomal protein uL16 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.