UniProt functional annotation for P0A7M6



	UniProt functional annotation for P0A7M6

UniProt code: P0A7M6.

Organism: Escherichia coli (strain K12).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: Binds 23S rRNA. It is not essential for growth. {ECO:0000269|PubMed:12226666, ECO:0000269|PubMed:6170935}.

Function: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Contacts trigger factor (PubMed:12226666). {ECO:0000269|PubMed:12226666}.

Subunit: Part of the 50s ribosomal subunit (PubMed:1092361, PubMed:10094780, PubMed:12809609, PubMed:16272117, PubMed:21499241, PubMed:25310980, PubMed:24844575, PubMed:27934701, PubMed:27906160, PubMed:27906161). Contacts protein L23 (PubMed:2665813), trigger factor (PubMed:12226666) and protein nascent chains (PubMed:12756233). Might also contact SecE and probably does contact SecG when the SecYEG translocation complex is docked with the ribosome (PubMed:16292303). {ECO:0000269|PubMed:10094780, ECO:0000269|PubMed:1092361, ECO:0000269|PubMed:12226666, ECO:0000269|PubMed:12756233, ECO:0000269|PubMed:12809609, ECO:0000269|PubMed:16272117, ECO:0000269|PubMed:21499241, ECO:0000269|PubMed:24844575, ECO:0000269|PubMed:25310980, ECO:0000269|PubMed:2665813, ECO:0000269|PubMed:27906160, ECO:0000269|PubMed:27906161, ECO:0000269|PubMed:27934701, ECO:0000305|PubMed:16292303}.

Mass spectrometry: Mass=7273.4; Method=MALDI; Evidence={ECO:0000269|PubMed:10094780};

Disruption phenotype: Cells missing both S17 and L29 grow very slowly and have a rather unstable temperature-sensitive phenotype. {ECO:0000269|PubMed:12226666, ECO:0000269|PubMed:3926498}.

Similarity: Belongs to the universal ribosomal protein uL29 family. {ECO:0000305}.

Sequence caution: Sequence=Ref.1; Type=Miscellaneous discrepancy; Note=Exchange of two tryptic peptides.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli (strain K12).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		Binds 23S rRNA. It is not essential for growth. {ECO:0000269\|PubMed:12226666, ECO:0000269\|PubMed:6170935}.



Function:		One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Contacts trigger factor (PubMed:12226666). {ECO:0000269\|PubMed:12226666}.


Subunit:		Part of the 50s ribosomal subunit (PubMed:1092361, PubMed:10094780, PubMed:12809609, PubMed:16272117, PubMed:21499241, PubMed:25310980, PubMed:24844575, PubMed:27934701, PubMed:27906160, PubMed:27906161). Contacts protein L23 (PubMed:2665813), trigger factor (PubMed:12226666) and protein nascent chains (PubMed:12756233). Might also contact SecE and probably does contact SecG when the SecYEG translocation complex is docked with the ribosome (PubMed:16292303). {ECO:0000269\|PubMed:10094780, ECO:0000269\|PubMed:1092361, ECO:0000269\|PubMed:12226666, ECO:0000269\|PubMed:12756233, ECO:0000269\|PubMed:12809609, ECO:0000269\|PubMed:16272117, ECO:0000269\|PubMed:21499241, ECO:0000269\|PubMed:24844575, ECO:0000269\|PubMed:25310980, ECO:0000269\|PubMed:2665813, ECO:0000269\|PubMed:27906160, ECO:0000269\|PubMed:27906161, ECO:0000269\|PubMed:27934701, ECO:0000305\|PubMed:16292303}.
Mass spectrometry:		Mass=7273.4; Method=MALDI; Evidence={ECO:0000269\|PubMed:10094780};
Disruption phenotype:		Cells missing both S17 and L29 grow very slowly and have a rather unstable temperature-sensitive phenotype. {ECO:0000269\|PubMed:12226666, ECO:0000269\|PubMed:3926498}.
Similarity:		Belongs to the universal ribosomal protein uL29 family. {ECO:0000305}.
Sequence caution:		Sequence=Ref.1; Type=Miscellaneous discrepancy; Note=Exchange of two tryptic peptides.; Evidence={ECO:0000305};