|
|
||
|
|
|
|
|
UniProt functional annotation for P75906 | ||
|
|
|
|
|
|
||
| UniProt code: P75906. |
|
||
| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
|
||
|
||
| Function: | |
Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D- glucosamine (PGA), a biofilm adhesin polysaccharide. N-deacetylation promotes PGA export through the PgaA porin. {ECO:0000269|PubMed:15090514, ECO:0000269|PubMed:18359807}. |
|
||
| Subcellular location: | |
Cell outer membrane {ECO:0000305|PubMed:18359807}; Lipid-anchor {ECO:0000305|PubMed:18359807}; Periplasmic side {ECO:0000305|PubMed:18359807}. |
| Domain: | |
Contains a N-terminal polysaccharide deacetylase domain, and a C-terminal domain required for PGA N-deacetylation that may be involved in binding to unmodified poly-beta-1,6-GlcNAc and thereby assists catalysis by the deacetylase domain. {ECO:0000269|PubMed:18359807}. |
| Disruption phenotype: | |
Deletion of pgaB does not prevent PGA synthesis but does block its export and biofilm formation. The synthesized PGA is retained in the periplasm and accumulates at the cell poles. {ECO:0000269|PubMed:15090514, ECO:0000269|PubMed:18359807}. |
| Similarity: | |
Belongs to the polysaccharide deacetylase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.