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UniProt functional annotation for Q9U6N3 | ||
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| UniProt code: Q9U6N3. |
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| Organism: | |
Leishmania infantum. |
| Taxonomy: | |
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania. |
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| Function: | |
DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. {ECO:0000256|RuleBase:RU366014}. |
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| Catalytic activity: | |
Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7; Evidence={ECO:0000256|ARBA:ARBA00001680, ECO:0000256|RuleBase:RU366014}; |
| Subcellular location: | |
Nucleus {ECO:0000256|RuleBase:RU366014}. |
| Similarity: | |
Belongs to the DNA polymerase type-X family. {ECO:0000256|RuleBase:RU366014}. |
Annotations taken from UniProtKB at the EBI.