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UniProt functional annotation for P9WQ35 | ||
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| UniProt code: P9WQ35. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Catalytic activity: | |
Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence={ECO:0000269|PubMed:11431477, ECO:0000269|PubMed:11447108, ECO:0000269|PubMed:16403515, ECO:0000269|PubMed:25295175}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:11431477, ECO:0000269|PubMed:11447108}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:11431477, ECO:0000269|PubMed:11447108}; Note=Binds 1 Mg(2+) ion per subunit (PubMed:25295175). Is also active with manganese ions (in vitro) (PubMed:11431477, PubMed:11447108). {ECO:0000269|PubMed:11431477, ECO:0000269|PubMed:11447108, ECO:0000269|PubMed:25295175}; |
| Subunit: | |
Homodimer (PubMed:11447108, PubMed:16403515, PubMed:25295175). Can also exist as monomer (PubMed:16403515, PubMed:25295175). {ECO:0000269|PubMed:11447108, ECO:0000269|PubMed:16403515, ECO:0000269|PubMed:25295175}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:11431477, ECO:0000269|PubMed:11447108}; Multi-pass membrane protein {ECO:0000305}. |
| Similarity: | |
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. {ECO:0000255|PROSITE-ProRule:PRU00099}. |
Annotations taken from UniProtKB at the EBI.