UniProt functional annotation for P15145



	UniProt functional annotation for P15145

UniProt code: P15145.

Organism: Sus scrofa (Pig).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.

Function: Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met-enkephalin but not cholecystokinin CCK8, neuromedin C (GRP-10), somatostatin-14, substance P and vasoactive intestinal peptide (PubMed:8963385). May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). {ECO:0000250|UniProtKB:P15144, ECO:0000250|UniProtKB:P97449, ECO:0000269|PubMed:8963385}.

Function: (Microbial infection) In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner. {ECO:0000269|PubMed:1350661, ECO:0000269|PubMed:7911642, ECO:0000269|PubMed:7913510, ECO:0000269|PubMed:8985407, ECO:0000269|PubMed:9634079}.

Catalytic activity: Reaction=Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.; EC=3.4.11.2; Evidence={ECO:0000269|PubMed:8963385};

Cofactor: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:22876187}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:22876187};

Subunit: Homodimer. Interacts with SLC6A19 (By similarity). {ECO:0000250|UniProtKB:P97449, ECO:0000269|PubMed:22876187, ECO:0000269|PubMed:6119979}.

Subunit: (Microbial infection) Interacts with TGEV and PRCoV spike glycoprotein. {ECO:0000269|PubMed:22876187, ECO:0000269|PubMed:7913510, ECO:0000269|PubMed:8985407, ECO:0000269|PubMed:9634079}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:7913510}; Single-pass type II membrane protein {ECO:0000305|PubMed:7913510}. Note=Also found as a soluble form. {ECO:0000250|UniProtKB:P15144}.

Ptm: Sulfated. {ECO:0000269|PubMed:3121301}.

Ptm: N- and O-glycosylated. {ECO:0000250|UniProtKB:P15144}.

Ptm: May undergo proteolysis and give rise to a soluble form. {ECO:0000250|UniProtKB:P15144}.

Similarity: Belongs to the peptidase M1 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Sus scrofa (Pig).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.



Function:		Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). It is able to degrade Leu-enkephalin and Met-enkephalin but not cholecystokinin CCK8, neuromedin C (GRP-10), somatostatin-14, substance P and vasoactive intestinal peptide (PubMed:8963385). May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). {ECO:0000250\|UniProtKB:P15144, ECO:0000250\|UniProtKB:P97449, ECO:0000269\|PubMed:8963385}.



Function:		(Microbial infection) In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner. {ECO:0000269\|PubMed:1350661, ECO:0000269\|PubMed:7911642, ECO:0000269\|PubMed:7913510, ECO:0000269\|PubMed:8985407, ECO:0000269\|PubMed:9634079}.


Catalytic activity:		Reaction=Release of an N-terminal amino acid, Xaa-\|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.; EC=3.4.11.2; Evidence={ECO:0000269\|PubMed:8963385};
Cofactor:		Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269\|PubMed:22876187}; Note=Binds 1 zinc ion per subunit. {ECO:0000269\|PubMed:22876187};
Subunit:		Homodimer. Interacts with SLC6A19 (By similarity). {ECO:0000250\|UniProtKB:P97449, ECO:0000269\|PubMed:22876187, ECO:0000269\|PubMed:6119979}.
Subunit:		(Microbial infection) Interacts with TGEV and PRCoV spike glycoprotein. {ECO:0000269\|PubMed:22876187, ECO:0000269\|PubMed:7913510, ECO:0000269\|PubMed:8985407, ECO:0000269\|PubMed:9634079}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:7913510}; Single-pass type II membrane protein {ECO:0000305\|PubMed:7913510}. Note=Also found as a soluble form. {ECO:0000250\|UniProtKB:P15144}.
Ptm:		Sulfated. {ECO:0000269\|PubMed:3121301}.
Ptm:		N- and O-glycosylated. {ECO:0000250\|UniProtKB:P15144}.
Ptm:		May undergo proteolysis and give rise to a soluble form. {ECO:0000250\|UniProtKB:P15144}.
Similarity:		Belongs to the peptidase M1 family. {ECO:0000305}.