PDBsum entry 4o6h

Hydrolase

PDB id: 4o6h

Contents

Protein chains

(+ 2 more) 203 a.a.

Ligands

IMD ×4

Metals

__K ×4

_ZN ×8

_MG ×4

References listed in PDB file

Key reference

• Title: Structure of the lcmv nucleoprotein provides a template for understanding arenavirus replication and immunosuppression.
• Authors: B.R.West, K.M.Hastie, E.O.Saphire.
• Ref.: Acta Crystallogr D Biol Crystallogr, 2014, 70, 1764-1769. [DOI no: 10.1107/S1399004714007883]
• PubMed id: 24914986

Abstract

The X-ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C-terminal immunosuppressive domain (LCMV NPΔ340) was determined to 2.0 Å resolution. The structure indicates that LCMV NPΔ340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three-dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus.