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UniProt functional annotation for Q9P371 | ||
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| UniProt code: Q9P371. |
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| Organism: | |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces. |
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| Function: | |
Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin- dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins. {ECO:0000250, ECO:0000269|PubMed:17660439}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250}; |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:16823372}. Endosome {ECO:0000269|PubMed:16823372}. |
| Domain: | |
The JAMM motif is essential for the protease activity. {ECO:0000250}. |
| Similarity: | |
Belongs to the peptidase M67C family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.