|
|
||
|
|
|
|
|
UniProt functional annotation for P04190 | ||
|
|
|
|
|
|
||
| UniProt code: P04190. |
|
||
| Organism: | |
Bacillus cereus. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group. |
|
||
|
||
| Function: | |
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Active on cephalosporin and penicillin. {ECO:0000269|PubMed:3930467}. |
|
||
| Catalytic activity: | |
Reaction=a beta-lactam + H2O = a substituted beta-amino acid; Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence={ECO:0000250|UniProtKB:P25910}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:20677753, ECO:0000269|PubMed:24059435, ECO:0000269|PubMed:26482303, ECO:0000269|PubMed:7588620, ECO:0000269|PubMed:9761898}; Note=Binds 2 Zn(2+) ions per subunit. The enzyme can also function with only 1 Zn(2+) ion (PubMed:9761898). {ECO:0000269|PubMed:20677753, ECO:0000269|PubMed:24059435, ECO:0000269|PubMed:26482303, ECO:0000269|PubMed:7588620, ECO:0000269|PubMed:9761898}; |
| Activity regulation: | |
Inhibited by captopril stereoisomers and iodoacetate (PubMed:3930467, PubMed:26482303). Also inhibited by chelating agents such as EDTA (PubMed:3930467). {ECO:0000269|PubMed:26482303, ECO:0000269|PubMed:3930467}. |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:3124808}. |
| Subcellular location: | |
Periplasm {ECO:0000305}. |
| Similarity: | |
Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.