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PDBsum entry 4n7b
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Oxidoreductase
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PDB id
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4n7b
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References listed in PDB file
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Key reference
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Title
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Structure of the (e)-4-Hydroxy-3-Methyl-But-2-Enyl-Diphosphate reductase from plasmodium falciparum.
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Authors
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I.Rekittke,
E.Olkhova,
J.Wiesner,
U.Demmer,
E.Warkentin,
H.Jomaa,
U.Ermler.
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Ref.
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Febs Lett, 2013,
587,
3968-3972.
[DOI no: ]
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PubMed id
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Abstract
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Terpenoid precursor biosynthesis occurs in human and many pathogenic organisms
via the mevalonate and 2-C-methyl-d-erythritol-4-phosphate (MEP) pathways,
respectively. We determined the X-ray structure of the Fe/S containing
(E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase (LytB) of the pathogenic
protozoa Plasmodium falciparum which catalyzes the terminal step of the MEP
pathway. The cloverleaf fold and the active site of P. falciparum LytB
corresponds to those of the Aquifex aeolicus and Escherichia coli enzymes. Its
distinct electron donor [2Fe-2S] ferredoxin was modeled to its binding site by
docking calculations. The presented structural data provide a platform for a
rational search of anti-malarian drugs.
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