UniProt functional annotation for Q9Y657



	UniProt functional annotation for Q9Y657

UniProt code: Q9Y657.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell- cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. {ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846}.

Subunit: Homodimer; may form higher-order oligomers (PubMed:17082182). Interacts with TCF7L2/TCF4; the interaction is direct (PubMed:22258766, PubMed:24589551, PubMed:29061846). Interacts with HABP4 and SERBP1 (By similarity). Interacts with C11orf84/SPINDOC (PubMed:29061846). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:17082182, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:23077255, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846}.

Subcellular location: Nucleus {ECO:0000269|PubMed:16098913, ECO:0000269|PubMed:29061846}. Nucleus, nucleolus {ECO:0000269|PubMed:21960006}.

Tissue specificity: Highly expressed in ovarian cancer tissues. {ECO:0000269|PubMed:22258766}.

Domain: The 3 tudor-like domains (also named Spin/Ssty repeats) specifically recognize and bind methylated histones (PubMed:23077255, PubMed:24589551). H3K4me3 and H3R8me2a are recognized by tudor-like domains 2 and 1, respectively (PubMed:24589551). {ECO:0000269|PubMed:17082182, ECO:0000269|PubMed:23077255, ECO:0000269|PubMed:24589551}.

Ptm: Phosphorylated during oocyte meiotic maturation. {ECO:0000250|UniProtKB:Q61142}.

Similarity: Belongs to the SPIN/STSY family. {ECO:0000305}.

Sequence caution: Sequence=AAD43035.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAG38112.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAG48367.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAB66653.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=CAG38515.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell- cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. {ECO:0000269\|PubMed:21960006, ECO:0000269\|PubMed:22258766, ECO:0000269\|PubMed:24589551, ECO:0000269\|PubMed:29061846}.


Subunit:		Homodimer; may form higher-order oligomers (PubMed:17082182). Interacts with TCF7L2/TCF4; the interaction is direct (PubMed:22258766, PubMed:24589551, PubMed:29061846). Interacts with HABP4 and SERBP1 (By similarity). Interacts with C11orf84/SPINDOC (PubMed:29061846). {ECO:0000250\|UniProtKB:Q61142, ECO:0000269\|PubMed:17082182, ECO:0000269\|PubMed:22258766, ECO:0000269\|PubMed:23077255, ECO:0000269\|PubMed:24589551, ECO:0000269\|PubMed:29061846}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:16098913, ECO:0000269\|PubMed:29061846}. Nucleus, nucleolus {ECO:0000269\|PubMed:21960006}.
Tissue specificity:		Highly expressed in ovarian cancer tissues. {ECO:0000269\|PubMed:22258766}.
Domain:		The 3 tudor-like domains (also named Spin/Ssty repeats) specifically recognize and bind methylated histones (PubMed:23077255, PubMed:24589551). H3K4me3 and H3R8me2a are recognized by tudor-like domains 2 and 1, respectively (PubMed:24589551). {ECO:0000269\|PubMed:17082182, ECO:0000269\|PubMed:23077255, ECO:0000269\|PubMed:24589551}.
Ptm:		Phosphorylated during oocyte meiotic maturation. {ECO:0000250\|UniProtKB:Q61142}.
Similarity:		Belongs to the SPIN/STSY family. {ECO:0000305}.
Sequence caution:		Sequence=AAD43035.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAG38112.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAG48367.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAB66653.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=CAG38515.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};