UniProt functional annotation for P15813



	UniProt functional annotation for P15813

UniProt code: P15813.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. {ECO:0000269|PubMed:17475845}.

Subunit: Heterodimer with B2M (beta-2-microglobulin). Interacts with MHC II. {ECO:0000269|PubMed:11927549, ECO:0000269|PubMed:16007090, ECO:0000269|PubMed:17581592}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:11927549, ECO:0000269|PubMed:17475845, ECO:0000269|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000305|PubMed:9973405}. Basolateral cell membrane {ECO:0000269|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000305|PubMed:9973405}. Endosome membrane {ECO:0000269|PubMed:11927549, ECO:0000269|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000305|PubMed:9973405}. Lysosome membrane {ECO:0000269|PubMed:17475845, ECO:0000269|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000269|PubMed:9973405}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11927549}; Single-pass type I membrane protein {ECO:0000269|PubMed:11927549}. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. {ECO:0000269|PubMed:9973405}.

Tissue specificity: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface. {ECO:0000250}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. {ECO:0000269\|PubMed:17475845}.


Subunit:		Heterodimer with B2M (beta-2-microglobulin). Interacts with MHC II. {ECO:0000269\|PubMed:11927549, ECO:0000269\|PubMed:16007090, ECO:0000269\|PubMed:17581592}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:11927549, ECO:0000269\|PubMed:17475845, ECO:0000269\|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000305\|PubMed:9973405}. Basolateral cell membrane {ECO:0000269\|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000305\|PubMed:9973405}. Endosome membrane {ECO:0000269\|PubMed:11927549, ECO:0000269\|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000305\|PubMed:9973405}. Lysosome membrane {ECO:0000269\|PubMed:17475845, ECO:0000269\|PubMed:9973405}; Single-pass type I membrane protein {ECO:0000269\|PubMed:9973405}. Endoplasmic reticulum membrane {ECO:0000269\|PubMed:11927549}; Single-pass type I membrane protein {ECO:0000269\|PubMed:11927549}. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. {ECO:0000269\|PubMed:9973405}.
Tissue specificity:		Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Miscellaneous:		During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface. {ECO:0000250}.