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PDBsum entry 4mq7
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Immune system
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PDB id
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4mq7
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References listed in PDB file
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Key reference
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Title
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Crystal structure of Vδ1 t cell receptor in complex with cd1d-Sulfatide shows mhc-Like recognition of a self-Lipid by human γδ t cells.
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Authors
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A.M.Luoma,
C.D.Castro,
T.Mayassi,
L.A.Bembinster,
L.Bai,
D.Picard,
B.Anderson,
L.Scharf,
J.E.Kung,
L.V.Sibener,
P.B.Savage,
B.Jabri,
A.Bendelac,
E.J.Adams.
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Ref.
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Immunity, 2013,
39,
1032-1042.
[DOI no: ]
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PubMed id
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Abstract
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The nature of the antigens recognized by γδ T cells and their potential
recognition of major histocompatibility complex (MHC)-like molecules has
remained unclear. Members of the CD1 family of lipid-presenting molecules are
suggested ligands for Vδ1 TCR-expressing γδ T cells, the major γδ
lymphocyte population in epithelial tissues. We crystallized a Vδ1 TCR in
complex with CD1d and the self-lipid sulfatide, revealing the unusual
recognition of CD1d by germline Vδ1 residues spanning all
complementarity-determining region (CDR) loops, as well as sulfatide recognition
separately encoded by nongermline CDR3δ residues. Binding and functional
analysis showed that CD1d presenting self-lipids, including sulfatide, was
widely recognized by gut Vδ1+ γδ T cells. These findings provide structural
demonstration of MHC-like recognition of a self-lipid by γδ T cells and
reveal the prevalence of lipid recognition by innate-like T cell populations.
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