|
|
||
|
|
|
|
|
UniProt functional annotation for Q8GCA8 | ||
|
|
|
|
|
|
||
| UniProt code: Q8GCA8. |
|
||
| Organism: | |
Bacillus megaterium. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Priestia. |
|
||
|
||
| Function: | |
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. {ECO:0000256|ARBA:ARBA00002869, ECO:0000256|HAMAP-Rule:MF_00260}. |
|
||
| Catalytic activity: | |
Reaction=H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+); Xref=Rhea:RHEA:13185, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57845, ChEBI:CHEBI:58126; EC=2.5.1.61; Evidence={ECO:0000256|ARBA:ARBA00000416, ECO:0000256|HAMAP- Rule:MF_00260}; |
| Cofactor: | |
Name=dipyrromethane; Xref=ChEBI:CHEBI:60342; Evidence={ECO:0000256|ARBA:ARBA00001916}; |
| Cofactor: | |
Name=dipyrromethane; Xref=ChEBI:CHEBI:60342; Evidence={ECO:0000256|HAMAP-Rule:MF_00260}; Note=Binds 1 dipyrromethane group covalently. {ECO:0000256|HAMAP- Rule:MF_00260}; |
| Subunit: | |
Monomer. {ECO:0000256|HAMAP-Rule:MF_00260}. |
| Miscellaneous: | |
The porphobilinogen subunits are added to the dipyrromethane group. {ECO:0000256|HAMAP-Rule:MF_00260}. |
| Similarity: | |
Belongs to the HMBS family. {ECO:0000256|ARBA:ARBA00005638, ECO:0000256|HAMAP-Rule:MF_00260}. |
Annotations taken from UniProtKB at the EBI.