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UniProt functional annotation for P9WMC1 | ||
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| UniProt code: P9WMC1. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH). {ECO:0000269|PubMed:10869356, ECO:0000269|PubMed:10944230}. |
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| Activity regulation: | |
Inhibited by tert-butyl 4-(3-thiophen-2-yl-1,2,4- oxadiazol-5-yl) piperidine-1-carboxylate (RF1) and 1-(thiophen-2- ylacetyl)-4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)piperidine (RF3). {ECO:0000269|PubMed:19412174}. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:15236969, ECO:0000269|PubMed:19412174}. |
| Disruption phenotype: | |
Cells lacking this gene leads to ETH hypersentivity. {ECO:0000269|PubMed:19412174}. |
| Miscellaneous: | |
Binding of inhibitors to EthR induces a conformational change in this repressor, which is then unable to bind its DNA operator, consequently allowing for increased transcription of EthA and bioactivation of ethionamide (ETH). |
Annotations taken from UniProtKB at the EBI.