UniProt functional annotation for D0C7F3



	UniProt functional annotation for D0C7F3

UniProt code: D0C7F3.

Organism: Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.

Function: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. {ECO:0000256|HAMAP-Rule:MF_00300}.

Catalytic activity: Reaction=5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate; Xref=Rhea:RHEA:21020, ChEBI:CHEBI:29748, ChEBI:CHEBI:43474, ChEBI:CHEBI:57701; EC=4.2.3.5; Evidence={ECO:0000256|ARBA:ARBA00001852, ECO:0000256|HAMAP- Rule:MF_00300, ECO:0000256|RuleBase:RU000605};

Cofactor: Name=FMNH2; Xref=ChEBI:CHEBI:57618; Evidence={ECO:0000256|ARBA:ARBA00001914};

Cofactor: Name=FMNH2; Xref=ChEBI:CHEBI:57618; Evidence={ECO:0000256|HAMAP-Rule:MF_00300, ECO:0000256|RuleBase:RU000605}; Note=Reduced FMN (FMNH(2)). {ECO:0000256|HAMAP-Rule:MF_00300, ECO:0000256|RuleBase:RU000605};

Pathway: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. {ECO:0000256|ARBA:ARBA00005044, ECO:0000256|HAMAP-Rule:MF_00300, ECO:0000256|RuleBase:RU000605}.

Subunit: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00300}.

Similarity: Belongs to the chorismate synthase family. {ECO:0000256|ARBA:ARBA00008014, ECO:0000256|HAMAP-Rule:MF_00300, ECO:0000256|RuleBase:RU000605}.

Annotations taken from UniProtKB at the EBI.


Organism:		Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.



Function:		Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. {ECO:0000256\|HAMAP-Rule:MF_00300}.


Catalytic activity:		Reaction=5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate; Xref=Rhea:RHEA:21020, ChEBI:CHEBI:29748, ChEBI:CHEBI:43474, ChEBI:CHEBI:57701; EC=4.2.3.5; Evidence={ECO:0000256\|ARBA:ARBA00001852, ECO:0000256\|HAMAP- Rule:MF_00300, ECO:0000256\|RuleBase:RU000605};
Cofactor:		Name=FMNH2; Xref=ChEBI:CHEBI:57618; Evidence={ECO:0000256\|ARBA:ARBA00001914};
Cofactor:		Name=FMNH2; Xref=ChEBI:CHEBI:57618; Evidence={ECO:0000256\|HAMAP-Rule:MF_00300, ECO:0000256\|RuleBase:RU000605}; Note=Reduced FMN (FMNH(2)). {ECO:0000256\|HAMAP-Rule:MF_00300, ECO:0000256\|RuleBase:RU000605};
Pathway:		Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. {ECO:0000256\|ARBA:ARBA00005044, ECO:0000256\|HAMAP-Rule:MF_00300, ECO:0000256\|RuleBase:RU000605}.
Subunit:		Homotetramer. {ECO:0000256\|HAMAP-Rule:MF_00300}.
Similarity:		Belongs to the chorismate synthase family. {ECO:0000256\|ARBA:ARBA00008014, ECO:0000256\|HAMAP-Rule:MF_00300, ECO:0000256\|RuleBase:RU000605}.