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PDBsum entry 4lfh
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Immune system
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PDB id
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4lfh
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References listed in PDB file
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Key reference
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Title
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Cd1d-Lipid antigen recognition by the γδ tcr.
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Authors
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A.P.Uldrich,
J.Le nours,
D.G.Pellicci,
N.A.Gherardin,
K.G.Mcpherson,
R.T.Lim,
O.Patel,
T.Beddoe,
S.Gras,
J.Rossjohn,
D.I.Godfrey.
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Ref.
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Nat Immunol, 2013,
14,
1137-1145.
[DOI no: ]
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PubMed id
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Abstract
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The T cell repertoire comprises αβ and γδ T cell lineages. Although it is
established how αβ T cell antigen receptors (TCRs) interact with antigen
presented by antigen-presenting molecules, this is unknown for γδ TCRs. We
describe a population of human Vδ1(+) γδ T cells that exhibit autoreactivity
to CD1d and provide a molecular basis for how a γδ TCR binds
CD1d-α-galactosylceramide (α-GalCer). The γδ TCR docked orthogonally, over
the A' pocket of CD1d, in which the Vδ1-chain, and in particular the germ
line-encoded CDR1δ loop, dominated interactions with CD1d. The TCR γ-chain sat
peripherally to the interface, with the CDR3γ loop representing the principal
determinant for α-GalCer specificity. Accordingly, we provide insight into how
a γδ TCR binds specifically to a lipid-loaded antigen-presenting molecule.
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