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UniProt functional annotation for Q9NPB1 | ||
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| UniProt code: Q9NPB1. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. {ECO:0000269|PubMed:10899995}. |
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| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| Subunit: | |
Homodimer. {ECO:0000305|PubMed:12352955}. |
| Subcellular location: | |
Mitochondrion {ECO:0000269|PubMed:10899995}. |
| Tissue specificity: | |
Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney and pancreas. {ECO:0000269|PubMed:10899995}. |
| Similarity: | |
Belongs to the 5'(3')-deoxyribonucleotidase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.