|
|
||
|
|
|
|
|
UniProt functional annotation for Q25595 | ||
|
|
|
|
|
|
||
| UniProt code: Q25595. |
|
||
| Organism: | |
Clonorchis sinensis (Chinese liver fluke). |
| Taxonomy: | |
Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda; Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis. |
|
||
|
||
| Function: | |
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000256|ARBA:ARBA00003701}. |
|
||
|
||
| Function: | |
GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. {ECO:0000256|ARBA:ARBA00002446}. |
|
||
| Catalytic activity: | |
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000256|ARBA:ARBA00000710}; |
| Subunit: | |
Homodimer. {ECO:0000256|ARBA:ARBA00011738}. |
| Similarity: | |
Belongs to the GST superfamily. Mu family. {ECO:0000256|ARBA:ARBA00005861}. |
Annotations taken from UniProtKB at the EBI.