PDBsum entry 4l5o

Transferase

PDB id: 4l5o

Contents

Protein chains

217 a.a.

Ligands

GSH ×3

SO4 ×6

Metals

_ZN ×2

Waters ×255

References listed in PDB file

Key reference

• Title: Crystal structures of 26kda clonorchis sinensis glutathione s-Transferase reveal zinc binding and putative metal binding.
• Authors: Y.H.Han, S.J.Hong, H.K.Cheong, Y.J.Chung.
• Ref.: Biochem Biophys Res Commun, 2013, 438, 457-461. [DOI no: 10.1016/j.bbrc.2013.07.102]
• PubMed id: 23916611

Abstract

The crystal structures of CsGST in two different space groups revealed that Asp26 and His79 coordinate a zinc ion. In one space group, His46 of an adjacent molecule participates in the coordination within 2.0Å. In the other space group, Asp26, His79 and a water molecule coordinate a zinc ion. The CsGST-D26H structure showed that four histidine residues - His26 and His79 from one molecule and the same residues from a symmetry-related neighboring molecule - coordinate a zinc ion. The coordinated zinc ions are located between two molecules and mediate molecular contacts within the crystal.