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UniProt functional annotation for P00709 | ||
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| UniProt code: P00709. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N- acetylglucosamine of the oligosaccharide chains in glycoproteins. |
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| Subunit: | |
Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA). |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Mammary gland specific. Secreted in milk. |
| Similarity: | |
Belongs to the glycosyl hydrolase 22 family. {ECO:0000255|PROSITE-ProRule:PRU00680}. |
Annotations taken from UniProtKB at the EBI.